LC-MS in Drug Bioanalysis -Timothy L. Madden Q. Alan Xu Book
LC-MS in Drug Bioanalysis
Author: Timothy L. Madden Q. Alan XuPublisher: SpringerCategory: Pharmacology, Analytical Chemistry, Chromatography, Spectrum Analysis, Spectrochemistry, Mass SpectrometryAge Group: 15+Book Format: PaperbackClinical pharmacology plays an important role in today's medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography - mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.
Table Of Contents
Internal standards for quantitative LC-MS bioanalysis.- Method development, validation and sample analysis for regulated quantitative bioanalysis using LC-MS/MS.- Impact of sampling paper/cards on bioanalytical quantitation via dried blood spots by liquid chromatography - mass spectrometry.- Highly sensitive pharmaceutical and clinical analysis using selective solid-phase extraction coupled to microflow liquid chromatography and isotope-dilution mass spectrometry.- Pitfalls of LC-MS/MS in the clinical laboratory.- Therapeutic drug monitoring to support clinical pharmacogenomics.- Liquid chromatography - mass spectrometry for the determination of antidepressants and some of their major metabolites in human biological matrices.- The analysis of antipsychotic drugs in human biosamples by LC-MS.- Therapeutic drug monitoring of targeted anticancer therapy - tyrosine kinase inhibitors and selective oestrogen receptor modulators: a clinical pharmacology laboratory perspective.- Applications of mass spectrometry in analyses of steroid hormones.- Liquid chromatography - mass spectrometric analysis of tropane alkaloids in mammalian samples: techniques and applications.- Analysis of illicit drugs in human biological samples by LC-MSn.- Use of matrix assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) in the development of novel small molecule drugs.- A planar integrated micro mass spectrometer.(BK-9781489990891)
| SKU | BK-9781489990891 |
| Barcode # | 9781489990891 |
| Brand | Springer |
| Artist / Author | Timothy L. Madden Q. Alan Xu |
| Shipping Weight | 0.6700kg |
| Shipping Width | 0.160m |
| Shipping Height | 0.030m |
| Shipping Length | 0.230m |
| Assembled Length | 23.400m |
| Assembled Height | 2.500m |
| Assembled Width | 15.600m |
| Type | Paperback |
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